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Mastering Nutrition

Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.
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Mastering Nutrition
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Now displaying: January, 2017
Jan 27, 2017

In episode 32, I tell the story of my personal story with iron overload, and weigh in on the proper use of blood tests and strategies to manage anemia, hemochromatosis, and everything in between. It's important to realize that these are the extremes, and there is a large middle space where we need to not only manage how much iron we accumulate, but how we direct it away from its disease-promoting roles and into its health-promoting roles.

This is a great primer on iron as well as a source of insights you may not have encountered elsewhere, such as the importance of oxidative stress as an independent regulator of ferritin, and the potential dangers of supplements designed to protect against oxidative stress like milk thistle, Protandim, sulforaphane, and green tea extract, for people at risk of anemia.

You can find the show notes to this episode at chrismasterjohnphd.com/32.

This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order.

In this episode, you will find all of the following and more: 0:33 Cliff Notes; 10:30 Introduction; 13:12 My personal story with iron overload; 30:12 The physiological roles of iron: hemoglobin, myoglobin, nitric oxide synthase, iron-sulfur clusters in the cytochromes of the electron transport chain, guanylyl cyclase, thyroid peroxidase (TPO), myeloperoxidase (MPO), oxygen transport, energy and ATP production, cellular regulation, thyroid hormone production, immunity; 38:20 Iron as a source of oxidative stress: free iron, hydrogen peroxide, and the hydroxyl radical, oxidative stress as an independent regulator of ferritin; 41:10 Regulation of iron status;
Ferritin, long-term storage, protector against pathogens, protector against oxidative stress; Transferrin, short-term iron storage; Hepcidin, master coordinator of iron metabolism; HFE, communicator between transferrin and hepcidin; 49:10 Regulation of dietary absorption of plant and animal iron; 51:00 Measuring and assessing iron status: complete blood count (MCH, MCV, RDW, CHr), full iron panel, sensitivity and specificity of transferrin saturation versus ferritin, differential interpretation of ferritin as a marker of iron overload, inflammation, or oxidative stress; 1:11:43 What to do for anemia: differentiate potential causes, iron in foods (heme, nonheme, vitamin C, polyphenols, phytate, calcium), iron in supplements (iron-saturated lactoferrin, heme iron, liposomal iron), avoid Nrf2-stimulating supplements (like Protandim, sulforaphane, milk thistle, green tea extract), importance of followup measurements of ferritin 01:21:03 What to do for iron overload: blood donation, dietary management, phlebotomy, chelation, importance of followup

 

Jan 26, 2017

In this special interlude, I lay down the framework of the five core principles that make a good marker of nutritional status. This is to lay down the framework for a series of podcasts in the future about managing nutritional status for specific vitamins and minerals.

Since these core principles will be referred back to as a general reference in so many other episodes, this one has a special place outside of the sequence and you can reach it at any time with the easy-to-remember URL chrismasterjohnphd.com/interlude.

This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order.

This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

In this episode, you will find all of the following and more: 37:23 Cliff Notes
09:25 Purpose of this podcast and its place in the upcoming series on managing nutritional status; 11:54 What are the five core principles? 12:05 Principle #1:
We understand its biochemistry and physiology; 15:04 Principle #2: It has been validated against changes in nutritional status; 17:17 Principle #3: Sensitivity; 17:52 Principle #4 Specificity; 19:45 Principle #5: It must be interpreted in the overall context of other markers and the clinical and health history, current signs and symptoms, and diet and lifestyle analysis; 23:20 Example of principle #1: Spectracell vs dp-ucMGP as tests of vitamin K2 status; 27:20 Example of principle #2: 25(OH)D vs. calcitriol; 29:20 Example of principle #3: transferrin saturation vs. ferritin
31:08 Example of principle #4: specificity of 25(OH)D and contexts where its specificity fails; 32:50 Example of principle #5: distinguishing between calcium and vitamin D deficiencies as causes of 25(OH)D by testing PTH, calcitriol, and analyzing the diet and lifestyle; 37:50 Shotgun approaches to nutritional testing; 40:30 Whether to act on leads from shotgun approaches should depend on the risks and other costs of the actions.

Jan 13, 2017

Glutathione is central to recovery from exercise, feeling good, looking good, aging gracefully, and preventing or overcoming both infectious diseases and chronic degenerative diseases. Episode 31 covers everything you need to know about why and how to manage your glutathione status.

This episode is brought to you by Kettle and Fire Bone Broth. Use the link kettleandfire.com/chris to get $10 off your first order.

This episode is also brought to you by US Wellness Meats. Head to grasslandbeef.com and enter "Chris" at checkout to get 15% off your order as long as the final price is over $75 and you order fewer than 40 pounds of meat. You can use "Chris" to get the same discount twice.

In this episode, you will find all of the following and more: 00:35 Cliff Notes; 10:45  Introducing my new health and wellness packages13:25 The health benefits of glutathione: master antioxidant, central to liver detoxification and the defense against glycation, master controller of hundreds of proteins, mucus fluidity, bronchodilation, anti-aging, protection against diabetes and its complications including cataracts and cardiovascular disease, protection against Hashimoto's thyroiditis and other thyroid disorders, protection against infectious diseases by supporting the immune system's respiratory (oxidative) burst, protection against congestion, COPD, asthma, and other lung problems; 25:15 How to measure glutathione status, the importance of measuring it in both is reduced (GSH) and oxidized disulfide (GSSG) forms, and using those to calculate your redox status using my glutathione redox status calculator30:28 The synthesis, recycling, and regulation of glutathione; 37:00      Practical strategies to improve glutathione status: protein, vitamin B6, carbohydrate, whey protein and raw milk, bone broth and collagen, magnesium, metabolic rate (ATP), polyphenols (e.g. EGCG and other green tea catechins) and other phytonutrients (e.g. sulforaphane) as Nrf2 inducers, glutathione in foods, N-acetyl-cysteine and glutathione supplements, insulin and insulin resistance, MTHFR mutations, glucose 6-phosphate dehydrogenase deficiency, niacin, riboflavin, and thiamin, why Jarrow oral glutathione is my current choice of supplement 1:04:24      Tying it all together.

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