In episode 40, I explain why glutathione survives digestion and can be absorbed intact, and why supplementing with it or eating it in foods helps support your health.
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This episode is a companion to Consuming Glutathione in Foods and Supplements, which has a searchable database of glutathione in 285 foods.
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In this episode, you will find all of the following and more:
0:00:38 Cliff Notes
0:08:22 What is glutathione and why is it important?
0:13:33 Special Masterclass With Masterjohn Pro discount for Mastering Nutrition listeners
0:20:10 Why does glutathione survive digestion?
0:20:50 How is glutathione absorbed intact?
0:35:48 Evidence for intact absorption of glutathione
0:36:00 Oral glutathione increases tissue glutathione in animals when glutathione synthesis is blocked with BSO.
0:38:12 Glutathione crosses CACO-2 monolayers, a model of human intestinal absorption, even when glutathione breakdown is inhibited with acivicin and glutathione synthesis is inhibited with BSO.
0:39:25 Isotopically labeled glutathione fed to mice enriches labeled glutathione in liver and red blood cell with no signs of the label in glutathione digestion products.
0:40:30 Glutathione supplements increase glutathione status in humans.
0:41:10 Caveats and contrary evidence.
0:48:15 What form of supplement (sublingual, liposomal, regular) is best?
0:56:10 What are the best specific supplements?
0:58:10 What dose should you use, and how should you know if you should use it?
0:58:43 Anecdote: 1 gram of glutathione relieves laughing-induced wheezing.
1:02:50 Glutathione in foods: reduced glutathione, total glutathione, glutathione-reactive substances, net glutathione
1:08:25 Glutathione content foods is not the be-all end-all of whether a food boosts glutathione status or whether it's healthy, but it's notable and important.