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Mastering Nutrition

Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.
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Now displaying: February, 2021
Feb 26, 2021

Question: What should someone with FH eat if they also have prediabetes?

So first of all, it's a separable component of the diet so you need a low-saturated fat, low-cholesterol diet without necessarily eating a low-fat diet. Then second of all, the effect of that on blood lipids is dependent on the healthfulness of your insulin pathway. And so over time, that's something where you can play the balance between those two things and as you improve your blood glucose handling, you can fit in more carbohydrates to have a fuller dietary effect.

For managing blood glucose, and I don't think it's a good idea to condemn all carbohydrates as a means of managing that. I think the best thing would be to get a continuous glucose monitor or a regular glucose monitor. If you're using a regular glucose monitor, use 30 minute, one hour, two hour, three hour, four hour time intervals after a meal and collect a baseline before a meal and look at how do different starches that you don't have an immunological response to... so you don't have to test grains because you don't tolerate them, but other foods that are rich in starches, whether it's carrots, or potatoes, or sweet potatoes, or whatever it is.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 25, 2021

Question: How should I take zinc if it makes me nauseous?

As far as I know, there's no relationship between the nausea and zinc deficiency. I could be wrong, maybe there's research on it I haven't seen or it could be not researched but I don't think there's a connection. My guess would be that that is either related to her ionizing it faster in the GI tract than you, or something else related to her nausea impulse that might be nutritional, it might be genetic, it might be male/female.

You could test out whether a little bit of bone broth or orange juice, or what have you with it buffers that enough to stop the nausea, and if it doesn't, I would just try to take it with a phytate-free meal. And by a phytate-free meal, I mean, a meal that doesn't have any whole grains, nuts, seeds, or legumes.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 24, 2021

Question: Can familial hypercholesterolemia be managed without statins?

I think there's the general perspective that there's no point in having LDL-C be any higher than 50; therefore, since it doesn't matter, let's provide a sufficient margin of error where we're real confident that getting it down to 100 is great and so why not get it down to 50? If there is any extra protection we get it and we don't lose it.

So my point of view would be, I would personally rather use a more conservative target of lowering down to 100 or so where the confidence is actually really high, because I'm not convinced by the lack of confidence that there's no neurological downside to pushing it twice as low as that. So that's my general perspective and if this were me, and it'll never be because I can't for the life of me get my total cholesterol above 160, but if it were me I'd be lowering my dose on that out of precaution on the other side.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 23, 2021

Question: Is this a biotin deficiency?

Beta-hydroxyisovaleric acid is well-established to be the most sensitive marker of biotin status. And actually typically it's done after leucine challenge, which is, no one does that. And so, generally in my experience, the way they have the reference ranges set on that should, on the ones that do have it, so the ION panel has it, the Genova panel has it, and the way they set the reference ranges, I think it works without the leucine challenge. But, I prefer the Genova ION panel because it has more, I just had a spreadsheet made up of the different markers that I wanted and the ones that were on the different organic acid panels and the ION panel has the most that line up with what, what I was looking for.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 22, 2021

Question: Why do vitamin E requirements stay elevated for four years when we stop eating PUFA?

None of this really proves that long-term vitamin E status is compromised, and that will make the clinical effect of PUFA be net negative after four or five years. But it does show you that the general relationship between the fact that you get more vitamin E when you eat PUFA oils, right? Because in the plant, the plant doesn't have this turnover problem, the plant makes vitamin E whenever it wants. And it has a certain amount of PUFA for some purpose, and it loads it up and so the plant has the amount of vitamin E that is needed to protect those under those conditions. So the question is, does a person, a human being, eating that oil also benefit from that relationship between vitamin E and PUFA that the safflower plant made? The answer to that is controversial.


Important note: In the video, a graph was shown that showed adipose linoleate is cleared in about one year rather than four. This was from an animal study. On page 30 in the PDF and 546 in the journal of this reference:

https://www.sciencedirect.com/science/article/abs/pii/0079683271900358

… it can be seen that it takes about 50 months (approximately 4 years) for adipose linoleate to bottom out in a human switched from corn oil to beef fat.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 16, 2021

Question: How long should our fasting windows be?

I think someone who eats three meals a day and no snacking is doing a form of intermittent fasting that most people aren't doing. And I don't even have a basis for believing whether that is superior, inferior, or the same as one meal a day in a 20 hour, four-hour feeding window. And so I think it's very clear that you want to cycle through the fed and fasted states. I think exactly how you do that is all trial and error and anecdotal accumulation of anecdotes and experiences at this point.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 15, 2021

Question: What is the value of third party genetic reports?

There are very, very few genes where we have really good information on how they impact nutritional requirements, but we have many, many, many genes where we have decent information on what they do mechanistically and where we can speculate things that might be helpful. So genome analysis is very useful as a brainstorming mechanism. And of course, there's genome sequencing in a clinical context to identify rare metabolic diseases, a totally different thing. That's obviously useful for where it's been defined as being useful, but doing a 23andMe analysis and submitting it to a report is useful for brainstorming and potentially generating some explanations for things that you observed.

And I think Self-Decode did a really good job in distilling, first of all, taking a lot of conflicting polymorphisms and distilling them into a net result. And then, second of all, distilling some actionable principles. Third of all, noting where they're brainstorming and providing references to give some reasonable level of confidence of exactly.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 12, 2021

Question: What is the value of the oxidized phospholipids test?

It's interesting to measure, but we don't have real strong data on its correlation to disease risk.  And we also don't really know how much it reflects the oxidation of lipoproteins in the subendothelial space, which is what matters.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 11, 2021

Question: Can NADH supplements cram more NADH into the system?

The NADH will be hydrolyzed to something along the lines of nicotinamide riboside, it will be absorbed and it will act like nicotinamide riboside does, which will increase the amount of nicotinamide stored in the liver for release to the tissues. And that will help increase their NADH levels.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 10, 2021

Question: How to avoid losing nutrients in fat thrown out from an organ meat blend

I don't think you're going to lose that many nutrients because the 25% fat, 75% lean ground beef mixed with those organs, most of that fat is coming from the marbling of the beef. That's not coming from the organ meats. Most of the nutrients in the organ meats, and they're not in marbled fat they're in cells and stuff.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 9, 2021

Question: How to manage the zinc-to-copper ratio?

I don't agree with using the zinc/copper ratio in testing. So it is the case that zinc and copper need to be in a very loose range of ratios. So you don't want your dietary zinc to be more than 15 times your dietary copper, and you don't want your dietary zinc to be less than two times your dietary copper. But other than that, you're really looking at them individually, and you're looking at, do I have enough zinc? Do I have enough copper? Do I have signs of zinc deficiency? Do I have signs of copper deficiency? Do I have signs of too much of one or the other? Much more than you're looking at the ratio.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 8, 2021

Question: Milk thistle, sulforaphane, and blood donation for iron overload

If it's an uptrend, you probably want to do something about it. Someone in that situation could try the Nrf2 stimulators, like milk thistle and sulforaphane. But if it is a genuine uptrend in early stage iron overload, that might be a situation that giving blood once a year would be the best solution.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 5, 2021

Question: Why would methylated vitamins increase pain sensitization?

I'm not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool of dopamine. There's going to be some degree to which it decreases other neuro-transmitters. And it's possible that if, particularly, if glycine is not stabilized, that you're going to lose the inhibitory effect of glycine and that you might also lose the effect of ambient glycine in coactivating NMDA receptors. Now off the top of my head, I would think that you would want the glycine there to support.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 4, 2021

Question: Why would ferritin and B12 increase on a low-calorie keto diet?

Ferritin is very strongly influenced by inflammation, oxidative stress. And so if the iron status is not changing and the ferritin is going up and then down, to me that suggests that oxidative stress or inflammation is increasing in the hypocaloric state. I was thinking maybe there's more PUFAs and stronger favoring of oxidative stress when there's more PUFAs released from adipose tissue during the hypercaloric during a hypocaloric state. 

So, all the PUFAs are being metabolized in the liver. And so there's probably oxidative stress increasing in the liver specifically in the hypocaloric diet, because the fatty acids are all being biased towards lipolysis from adipose tissue straight to the liver for beta-oxidation. And I think that's dramatically increasing the oxidative burden on the liver and there's short term damage being done in the liver that's increasing the B12 and ferritin levels.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 3, 2021

Question: Why are polyunsaturated fats more easily burned for energy than saturated fats?

I don't know in detail the mechanism, but I do know that it's been shown in human cells and in live animal experiments. And it presumably is related to the affinity of the enzyme for the fatty acid. And that's not something that's biochemically difficult. It's normal if there are enzymes that work with any fatty acid, for them to have different affinities for some fatty acids versus others.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 2, 2021

Question: Why zinc deficiency causes resistance to thyroid and sex hormones and vitamins A and D

The answer to that is because the, because all of those things carry out their gene expression function by binding to nuclear receptors. And all of the nuclear receptors to DNA using zinc finger motifs. Zinc finger motif means that in the nuclear receptor, there's a zinc ion that coordinates the primary structure of the protein, which is a long string of amino acids into a finger shape.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at
https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Feb 1, 2021

Question: Which nutrients do we need every single day?

I would say that the top ones to be concerned about from a have-to-get-it-today perspective would be zinc and B12. And both of those have absorption caps that are fairly tight, but B12 is the number one concern.

You want to pay decent attention to the zinc rule, and you do want to make sure that your B vitamins are getting in on most of those other B vitamins you could probably, as long as you're hitting the daily average on the weekly basis, that's good.

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, a private discussion group, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up at https://chrismasterjohnphd.com/masterpass/ and use the code QANDA to get 10% off the membership for life.

From now through March, I will be working full-time on finishing my Vitamins and Minerals 101 book, while reserving a portion of my time for consulting clients. You can pre-order my book at https://chrismasterjohnphd.com/book. You can sign up for a consultation at https://chrismasterjohnphd.com/consultations.

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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