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Mastering Nutrition

Hi, I'm Chris Masterjohn and I have a PhD in Nutritional Sciences. I am an entrepreneur in all things fitness, health, and nutrition. In this show I combine my scientific expertise with my out-of-the-box thinking to translate complex science into new, practical ideas that you can use to help yourself on your journey to vibrant health. This show will allow you to master the science of nutrition and apply it to your own life like a pro.
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Now displaying: 2021
Sep 3, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Sep 2, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Sep 1, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 31, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 30, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 27, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 26, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 25, 2021

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 24, 2021

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If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 23, 2021

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Question: How should you program the temperature on an Ooler or Eight Sleep?

The way that I do it is, if I wake up feeling cold, I want to program it to increase the temperature at that time point so that I do not wake up cold. So, I would say, generally speaking, you want it as cold as it can be starting, that does not interfere with your sleep, and you want it as cold as can be in the middle of the night, that does not wake you up. So, I think that's going to be very different for each person, and I think whatever temperature prevents you from waking up cold, is the one you want.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 20, 2021

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Question: Is it useful to measure HVA, VMA, and 5-HIAA?

I find them useful in a very limited context. The limitation of their usefulness is basically that you can't really tell if something is high or low because of production or degradation.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 19, 2021

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Question: What nutrients require insulin to get into cells?

Magnesium phosphorus and potassium are the big ones that are going to have poor uptake in response to insulin.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 18, 2021

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Question: What are the top whole food supplements to take?

I mean, that's kind of too general a question, especially for end of the AMA rapid-fire. I don't make blanket supplements suggestions, but in the likes of Oystermax, an organ mix or liver supplement from Ancestral or from Paleovalley, although their organ mix is a sold out, and nutritional yeast, I think are great components of a natural, DIY, whole food multivitamin.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 17, 2021

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Question: Could iron deficiency create a complex 1 disorder?

If you're iron deficient and you have blood work that looks like a complex 1 block, and you feel like you have an energy metabolism disorder, then, while it is possible you have a genetic complex 1 deficiency, it's also possible you have an iron deficiency that is not playing out in your CBC or your thyroid panel that is impacting your energy metabolism.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 16, 2021

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Question: How to get more sulfate if you have sulfite issues?

If you're not converting sulfite to sulfate, that should be a molybdenum deficiency. If it's not a molybdenum deficiency it's probably a gut microbiota problem. Could be a sulfite oxidase enzyme deficiency, of course, but I think it would be much more common that you have sulfate metabolizing bacteria in the intestines, then that you have a sulfite oxidase genetic deficiency. Although, you can never rule out a modest impairment in that enzyme, that would not be diagnosed with anything. So, it can't be ruled out. But I do you think it's going to be much more common that someone has a sulfur intolerance that's driven by gut microbiota.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 13, 2021

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Question: If you're eating oysters, do you need to eat liver too?

And I think oysters are more reliably a source of zinc relative to copper and relative to liver. And liver is much more consistently a source of copper relative to zinc and relative to oysters. And so I stand by what I said in terms of taking into account the variation in different species of oyster, in different oceans and different batches of oyster products, but Oystermax does batch testing.


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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 12, 2021

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Question: Lipoic acid: does it need to be the R form?

Lipoic acid can help with blood sugar and it is an antioxidant. I would always use R-Lipoic acid. I would never use the racemic mixture of alpha-lipoic acid because the R form is the biologically active one. And I think it might be the case that you can just take a higher dose, but why mess around with the possibility that some isomer that doesn't belong in your body and isn't found in food, isn't going to interfere with the function of the R form. So I would just take R- Lipoic acid for any purpose at all.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 11, 2021

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Question: How much fruit is it safe to eat at once?

I don't really agree with that premise and that premise might be sensible at really high fructose intake, but I don't think many people are going to hit that by eating fruit, unless they're on a fruitarian diet. I think if you're eating 1, 2, 3 servings of fruit at a time, you're probably not going to seriously hit that mark, but that depends on your energy metabolism and the rest of your diet. So I think the metric to look at that would be your uric acid levels. If your uric acid levels are high, you are eating a lot of fruit at one sitting.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 10, 2021

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Question: Should I supplement NAC if cysteine, taurine, and sulfate are low?

You can supplement NAC, but you probably just need more animal protein. Although a vegan could supplement NAC instead of animal protein. If your homocysteine is on the high side, then you definitely want to increase methionine in order to increase SAMe to increase the breakdown of homocysteine.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 9, 2021

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Question: Iron deficiency without anemia?

I would just say that I would be wary of iron deficiency, even if it's not causing anemia, because iron plays roles in energy metabolism, detoxification, and thyroid metabolism separate from anemia. But the things that are easiest to test are thyroid panel and CBC. So if your thyroid panel and your CBC look great, you probably aren't truly iron deficient, but I would also measure it against symptoms. So for example, if you have unexplained fatigue and you feel much better when you get more iron in your diet, I would interpret that as iron deficiency, that probably is just most sensitively affecting the electron transport chain if it's not showing up in a CBC or a thyroid panel.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 6, 2021

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Question: How to Calculate the Amount of a Nutrient in a Complex

So this is how to know what percent of something in a complex form gives you what percent of the nutrient of interest, if you ever want to calculate it yourself. So what you want to do, let's say you want to know what percent of Alpha-GPC is choline. What you want to do is say Alpha-GPC, molar mass and Google gives it to you right here, 257.221. And then you want to say choline molar mass 104.1708 and so you want to take this number, the nutrient of interest, and you want to divide it by this number, the dose of the complex form. And then you would get 0.404985. So to carry it out to two digits that rounds down to 0.4. Alpha-GPC is 40% choline. And if you want to find amount of choline in Alpha-GPC, you take the dose of Alpha-GPC and you multiply it by 0.4. Or if you want to be highly specific, you multiply it by this number and you can do the exact same thing for magnesium glycinate, iron bisglycinate, et cetera.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 5, 2021

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Question: Eggs, Choline Bisulfate, and TMAO

If you really want to know what eggs are doing to your TMAO, then I'm pretty sure Cleveland Clinic has a TMAO blood test, and that would be the best way to do it. Yeah, the Cleveland heart lab has a TMAO blood test, so you could test your response to this. If you didn't want to test, then if you assumed the worst case scenario, I would say you could probably just eat two eggs at a time and you would not raise your TMAO that much, but if you do test TMAO, you can probably show that you might be able to get away with eating six eggs at a time and not raise your TMAO that much.

But the thing is, I don't think you're going to get the same response from six eggs at a time as in that study, as you would get from eating two eggs separated and spread out from the day. And the reason is I think the TMAO is mostly generated from the choline that does not get absorbed in the small intestine, going to the colon, being available to the microbiome. So if you lower the dose of eggs and spread them out, then you should be able to kind of totally head off significant TMAO generation. 

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 4, 2021

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Question: Floxed: How to Recover From Cipro

And a lot of these things probably have nothing to do with hydration, but are a direct result, or rather not direct, but a secondary indirect result of the failure of mitochondrial energy metabolism. So, I have been doing some limited research on Cipro and brainstorming some educated guesswork around recovering mitochondrial energy metabolism health. And there are multiple hypotheses around Cipro toxicity mechanisms, but the bulk of the thought is in damaging mitochondrial DNA and basically just leading to defective mitochondria. And so it seems to me like the best strategies around regaining health after Cipro toxicity, and this is all educated guesswork, none of this is tested in randomized controlled trials, and I'm not a medical doctor, and this is not medical advice, but it seems like the most promising hypotheses would be around promoting mitophagy and mitochondrial biogenesis. And so probably whatever you can do to maximize the depth of your cycling in the fast and fed states is probably the most promising thing you can do for mitochondrial turnover.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 3, 2021

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Question: If you correct a deficiency too fast, can you make it worse?

I think the answer is no. And I definitely don't think that happens, and I've never seen anything to suggest that happens.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Aug 2, 2021

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Question: If my methionine is high, do I need to worry about betaine?

If your methionine is on the higher side then it's probably the case that you don't really have an issue with recycling homocysteine to methionine. TMG's role in methylation is to support the recycling of homocysteine methionine. So if your methionine levels are on the high side of normal then you probably don't need TMG, but I'm also not sure what you mean by methylation issues.

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

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