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Question: High-dose EPA, triglycerides, and general health
It's definitely the case that high dose EPA lowers triglyceride levels in people with high triglycerides. And it does that by interfering with carbohydrate signaling. So carbohydrate signaling, part through glucose itself, and part through insulin, increases triglyceride synthesis and in insulin resistant people, generally the average person with insulin resistance has an amplification of that pathway and is actually hypersensitive to it while being resistant to glucose handling part of the pathway. So blood glucose and blood triglycerides increase. And if you take high-dose EPA, you will interfere with the signaling and you will lower the triglycerides.
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.