Question: Should NAC supplementation be pulsed?
So, yes, boost glutathione. It might bring glutathione down. It's speculative that you could pulse it to avoid that. But even supplementing oral glutathione for 6 months was shown to not affect glutathione production. And certainly, oral glutathione is going to have more of a negative feedback loop than a glutathione precursor. So, I am not too worried about it.
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.