Question: Why would methylated vitamins increase pain sensitization?
I'm not sure. Just to throw out some random threads that may or may not be of use. I think methylation in some people is going to lead to increased synthesis of dopamine. But in general, the effect is going to be to decrease the tonic pool of dopamine. There's going to be some degree to which it decreases other neuro-transmitters. And it's possible that if, particularly, if glycine is not stabilized, that you're going to lose the inhibitory effect of glycine and that you might also lose the effect of ambient glycine in coactivating NMDA receptors. Now off the top of my head, I would think that you would want the glycine there to support.
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.