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Question: What does it mean if you're helped by SAMe?
It could indicate that, or it could indicate that they have an impairment in the conversion of methionine to SAMe, which could be mediated by low magnesium status, low ATP status, or a poorly functioning MAT, methionine adenosyltransferase gene.
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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.